BiologicalActivity
Orallyactive,fullagonistat5-HT1Areceptors.Bindsrat5-HT1Awithhighaffinity(Ki=2.0nM)andis>300-foldselectiveoverother5-HTreceptorsubtypes(IC50>650nM).IncreasesmotoneuronsurvivalandpromoteseffectsofNGFonneuriteoutgrowthinvitro.Displaysneurotrophicactivityinseveralneurodegenerativemodelsinvivo. .
CompoundLibraries
XaliprodenhydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 417.9 |
| Formula | C24H22F3N.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 90494-79-4 |
| PubChemID | 128918 |
| InChIKey | WVHBEIJGAINUBW-UHFFFAOYSA-N |
| Smiles | Cl.FC(F)(F)C1=CC(=CC=C1)C1=CCN(CCC2=CC=C3C=CC=CC3=C2)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.79 | 100 | |
| ethanol | 8.36 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight417.9.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.39mL | 11.96mL | 23.93mL |
| 5mM | 0.48mL | 2.39mL | 4.79mL |
| 10mM | 0.24mL | 1.2mL | 2.39mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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