BiologicalActivity
CannabinoidagonistwhichisconsiderablymorepotentthanΔ9-THCinbothbehavioraltestsandreceptorbindingassays.Displayshighandroughlyequalaffinityforbothcentralandperipheralcannabinoidreceptors(Ki=0.6-5.0and0.7-2.6nMatCB1andCB2respectively;EC50valuesare0.2,0.3and5nMatCB1,CB2andGRP55respectively).
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
TechnicalData
| M.Wt | 376.58 |
| Formula | C24H40O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 83002-04-4 |
| PubChemID | 104895 |
| InChIKey | YNZFFALZMRAPHQ-SYYKKAFVSA-N |
| Smiles | O[C@H]1C[C@@H]([C@]2=CC=C(C(C)(C)CCCCCC)C=C2O)[C@H](CCCO)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.66 | 100 | |
| ethanol | 37.66 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight376.58.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.66mL | 13.28mL | 26.55mL |
| 5mM | 0.53mL | 2.66mL | 5.31mL |
| 10mM | 0.27mL | 1.33mL | 2.66mL |
| 50mM | 0.05mL | 0.27mL | 0.53mL |
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