BiologicalActivity
Mixedopioidreceptoragonist/antagonist.Actsasapotentandfullagonistatκ,apartialagonistatμandδopioidreceptors(pEC50valuesare9.45,8.74and8.61inacAMPassay,9.70,8.59and8.49ina[35S]GTPγSbindingassayrespectively).FailstoexertagonisteffectsatNOPreceptorsandantagonizesagonist-inducedNOPactivation.Stimulatesκ-,μ-andδ-mediatedanalgesiaandblocksNOP-inducedsupraspinalnociception.
TechnicalData
| M.Wt | 445.52 |
| Formula | C26H27N3O4 |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 119630-94-3 |
| PubChemID | 9601084 |
| InChIKey | AKXCFAYOTIEFOH-XTNAHFASSA-N |
| Smiles | O[C@@]23[C@@]([C@]5([H])/C(CC3)=N/NC(C6=CC=CC=C6)=O)(CC4)C1=C(O5)C(O)=CC=C1C[C@H]2N4CC=C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.28 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight445.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.24mL | 11.22mL | 22.45mL |
| 5mM | 0.45mL | 2.24mL | 4.49mL |
| 10mM | 0.22mL | 1.12mL | 2.24mL |
| 50mM | 0.04mL | 0.22mL | 0.45mL |
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