BiologicalActivity
HighaffinityandselectiveCB2inverseagonist(Ki=0.6nM).Exhibits>700-foldselectivityforCB2overCB1receptors.BlockstheeffectsofCP55,940(Cat.No.0949)onforskolin-sensitiveadenylylcyclaseactivityandMAPKinCHOcellsexpressingCB2receptors.AlsoblocksCP55,940-inducedB-cellactivation.Orallybioavailable.
TechnicalData
| M.Wt | 476.05 |
| Formula | C29H34ClN3O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 192703-06-3 |
| PubChemID | 3081355 |
| InChIKey | SUGVYNSRNKFXQM-XRHWURSXSA-N |
| Smiles | C[C@]1(C2)[C@H](NC(C3=NN(CC4=CC=C(C)C=C4)C(C5=CC=C(Cl)C(C)=C5)=C3)=O)C(C)(C)[C@@H]2CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.6 | 100 | |
| ethanol | 47.6 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight476.05.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.1mL | 10.5mL | 21.01mL |
| 5mM | 0.42mL | 2.1mL | 4.2mL |
| 10mM | 0.21mL | 1.05mL | 2.1mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
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