BiologicalActivity
Potentβ3-adrenergicreceptorpartialagonist>1000-foldselectiveoverβ1-andβ2-adrenoceptors(EC50valuesare0.43,580and>10000nMforactivationofclonedhumanβ3-,β1-andβ2-adrenoceptorsrespectively).StimulateslipolysisinrhesusADIpocytesinvitro(EC50=3.9nM).EnhancesCRISPR-mediatedhomology-directedrepair(HDR)efficiency2-3-foldforlargefragmentsand~9-foldforpointmutations,inhumaninducedpluripotentstemcells(iPSCs).
CompoundLibraries
L-755,507isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 584.73 |
| Formula | C30H40N4O6S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 159182-43-1 |
| PubChemID | 9829836 |
| InChIKey | NYYJKMXNVNFOFQ-MHZLTWQESA-N |
| Smiles | O=S(C1=CC=C(NC(NCCCCCC)=O)C=C1)(NC2=CC=C(CCNC[C@H](O)COC3=CC=C(O)C=C3)C=C2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.47 | 100 | |
| ethanol | 58.47 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight584.73.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.71mL | 8.55mL | 17.1mL |
| 5mM | 0.34mL | 1.71mL | 3.42mL |
| 10mM | 0.17mL | 0.86mL | 1.71mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
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