Tocris一级代理 Tocris配体,Tocris/GW 9508/2649/50/50 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/GW 9508/2649/50/50 mg

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Tocris

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2649/50

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4000-520-616

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Description:PotentandselectiveFFA1(GPR40)agoNIST

ChemicalName:4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoicacid

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveagonistforthefreefattyacidreceptorFFA1(GPR40)(pEC₅₀valuesare7.32,<4.3and<4.3forFFA1,FFA2andFFA3receptorsrespectively).InactiveagainstarangeofotherGPCRs,kinases,proteases,integrinsandPPARs.Potentiatesglucose-stimulatedinsulinsecretioninMIN6cells(pEC₅₀=6.14).

LicensingInformation

SoldwiththepermissionofGlaxoSmithKline

CompoundLibraries

GW9508isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	347.41
Formula	C₂₂H₂₁NO₃
Storage	StoreatRT
Purity	≥99%(HPLC)
CASNumber	885101-89-3
PubChemID	11595431
InChIKey	DGENZVKCTGIDRZ-UHFFFAOYSA-N
Smiles	OC(=O)CCC1=CC=C(NCC2=CC=CC(OC3=CC=CC=C3)=C2)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	34.74	100
	ethanol	34.74	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight347.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.88mL	14.39mL	28.78mL
5mM	0.58mL	2.88mL	5.76mL
10mM	0.29mL	1.44mL	2.88mL
50mM	0.06mL	0.29mL	0.58mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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