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Tocris/Ginkgolide B/1657/10/10 mg

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Tocris

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1657/10

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4000-520-616

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Description:PAFreceptorantagoNIST

AlternativeNames:BN52021

ChemicalName:(1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Platelet-activatingfactor(PAF)receptorantagonist(K_i=1.3μM).Inhibitsneutrophildegranulationandsuperoxideproductioninvitroandinhibitsbronchoconstrictionandisneuroprotectivefollowingoraladministrationinvivo.

CompoundLibraries

GinkgolideBisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	424.4
Formula	C₂₀H₂₄O₁₀
Storage	Desiccateat+4°C
CASNumber	15291-77-7
PubChemID	10971931
InChIKey	SQOJOAFXDQDRGF-OTJOYSMWSA-N
Smiles	O=C1[C@@H](C)[C@@]2(O)[C@@]([C@H](O)C34[C@]52O[C@@]6([H])[C@]([C@@H](O)C(O6)=O)3[C@H]([C@](C)(C)C)C[C@H]4O[C@]5=O)([H])O1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	42.44	100
	ethanol	10.61	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight424.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.36mL	11.78mL	23.56mL
5mM	0.47mL	2.36mL	4.71mL
10mM	0.24mL	1.18mL	2.36mL
50mM	0.05mL	0.24mL	0.47mL

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BiologicalActivity

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