品牌试剂实验Tocris代理 Tocris Bioscience授权代理商，正品,Tocris/ICI 182,780/1047/1/1 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/ICI 182,780/1047/1/1 mg

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Tocris

货号 /

1047/1

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4000-520-616

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Description:EstrogenreceptorantagoNIST

ChemicalName:7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Ahighaffinityestrogenreceptorantagonist(IC₅₀=0.29nM),devoidofanypartialagonismbothinvitroandinvivo.AlsohighaffinityagonistatthemembraneestrogenreceptorGPER.

LicensingInformation

SoldwiththepermissionofAstraZenecaUKLtd.

CompoundLibraries

ICI182,780isalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	606.77
Formula	C₃₂H₄₇F₅O₃S
Storage	StoreatRT
Purity	≥99%(HPLC)
CASNumber	129453-61-8
PubChemID	17756771
InChIKey	VWUXBMIQPBEWFH-LQKBAPIOSA-N
Smiles	OC1=CC=C2C(C[C@@H](CCCCCCCCCS(CCCC(F)(C(F)(F)F)F)=O)C3([H])[C@@]([H])2CC[C@@]4(C)[C@@](CC[C@@H]4O)3[H])=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	60.68	100
	ethanol	30.34	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight606.77.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.65mL	8.24mL	16.48mL
5mM	0.33mL	1.65mL	3.3mL
10mM	0.16mL	0.82mL	1.65mL
50mM	0.03mL	0.16mL	0.33mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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