BiologicalActivity
PotentSmoantagonist(IC50=7.6nM).SelectivelyinhibitsHedgehogsignalingoverWntandNotchsignalingpathways.BlocksSmoaccumulationinprimaryciliuminvitro.FluorescentanalogIHR-Cy3alsoavailable.
TechnicalData
| M.Wt | 454.13 |
| Formula | C20H12Cl4N2O2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 548779-60-8 |
| PubChemID | 2167042 |
| InChIKey | VCLHHRGZKNUOAQ-UHFFFAOYSA-N |
| Smiles | ClC1=CC(C(NC2=CC=C(NC(C3=C(Cl)C=CC(Cl)=C3)=O)C=C2)=O)=C(Cl)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.08 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight454.13.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.2mL | 11.01mL | 22.02mL |
| 5mM | 0.44mL | 2.2mL | 4.4mL |
| 10mM | 0.22mL | 1.1mL | 2.2mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
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