BiologicalActivity
Endogenousarylhydrocarbonreceptor(AhR)agonist(Ki=3nM).DecreasesOct4levelsinU87glioblastomacells.Inducesstem-likecancercelldifferentiationinU87tumorspheresandinhibitsovariancancercellproliferationinvitro.SuppressestumorgrowthinU87andOVCAR-3cellxenograftsinmice.AlsoinhibitsTGF-β-inducedhumanmyofibroblastdifferentiation.
LicensingInformation
Soldunderlicense,USPatentApplication2002183524
CompoundLibraries
ITEisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 286.3 |
| Formula | C14H10N2O3S |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 448906-42-1 |
| PubChemID | 4668801 |
| InChIKey | KDDXOGDIPZSCTM-UHFFFAOYSA-N |
| Smiles | COC(=O)C1=CSC(=N1)C(=O)C1=CNC2=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.63 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight286.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.49mL | 17.46mL | 34.93mL |
| 5mM | 0.7mL | 3.49mL | 6.99mL |
| 10mM | 0.35mL | 1.75mL | 3.49mL |
| 50mM | 0.07mL | 0.35mL | 0.7mL |
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