BiologicalActivity
Selectiveσ1receptorligand(KD=19.1nM),withlittleornoactivityatσ2receptors(IC50>1000nM).InhibitstheNMDA-inducedincreaseincGMPinaconcentration-dependentmanner(IC50valueisapproximately100nM).Weakinhibitorofbrain5-HTuptakeinvitro.Exhibitsneuroprotectiveandantidepressanteffects.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
TechnicalData
| M.Wt | 355.94 |
| Formula | C23H29N.HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 130152-35-1 |
| PubChemID | 6438339 |
| InChIKey | SCHQQPAJNUHKSV-RSGUCCNWSA-N |
| Smiles | CN(C(CC)(C3=CC=CC=C3)C/C=C/C2=CC=CC=C2)CC1CC1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.8 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight355.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.81mL | 14.05mL | 28.09mL |
| 5mM | 0.56mL | 2.81mL | 5.62mL |
| 10mM | 0.28mL | 1.4mL | 2.81mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |
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