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Description:SMOantagoNIST;actsatdifferentbindingsitetocyclopamine(CatNo.1623)
ChemicalName:4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
SMOantagonist(IC50=690nM);actsatdifferentbindingsitetocyclopamine(Cat.No.1623).Alsocytochromep450inhibitor(IC50=16-26nM).InhibitscellcycleatG1phaseinvitroandblocksangiogenesisinvivo(IC50=160nM).Antifungal.
TechnicalData
M.Wt | 705.63 |
Formula | C35H38Cl2N8O4 |
Storage | Storeat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 84625-61-6 |
PubChemID | 3793 |
InChIKey | VHVPQPYKVGDNFY-UHFFFAOYSA-N |
Smiles | CCC(N1N=CN(C2=CC=C(N3CCN(C4=CC=C(C=C4)OC[C@H]5CO[C@@](O5)(C6=C(C=C(C=C6)Cl)Cl)CN7C=NC=N7)CC3)C=C2)C1=O)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 14.11 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight705.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.42mL | 7.09mL | 14.17mL |
5mM | 0.28mL | 1.42mL | 2.83mL |
10mM | 0.14mL | 0.71mL | 1.42mL |
50mM | 0.03mL | 0.14mL | 0.28mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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