BiologicalActivity
α2C-adrenoceptorantagonistthatdisplays~50-foldselectivityoverotherα2-adrenoceptorsubtypes(Kivaluesare28,1470,1700and3150nMforhumanα2C,α2B,α2Dandα2Asubtypesrespectively).Potentlyantagonizesadrenalin-stimulated35GTPγSbindinginvitro(KB=16nM)andproducesantidepressantandantipsychotic-likeeffectsinvivo.
TechnicalData
| M.Wt | 441.4 |
| Formula | C24H24N4.2HCl |
| Storage | Desiccateat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1259314-65-2 |
| PubChemID | 49855035 |
| InChIKey | VVZOADYFJAJZGL-UHFFFAOYSA-N |
| Smiles | CN(CC5)CCN5C(C=C4)=CC=C4NC2=C3C(C=CC=C3)=NC1=CC=CC=C12.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.2 | 5 | |
| water | 44.14 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight441.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.27mL | 11.33mL | 22.66mL |
| 5mM | 0.45mL | 2.27mL | 4.53mL |
| 10mM | 0.23mL | 1.13mL | 2.27mL |
| 50mM | 0.05mL | 0.23mL | 0.45mL |
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