BiologicalActivity
PotentPPARδagonist(Ki=6nM);displays>100-foldselectivityforbothmouseandhumanPPARδ receptorsoverothersubtypes.Raisesplasmacholesterollevelsinvivo,ininsulin-resistantdb/dbmice.NeuroprotectiveinmodelsofcerebralinfarctionandParkinson'sdisease.
CompoundLibraries
L-165,041isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 402.44 |
| Formula | C22H26O7 |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 79558-09-1 |
| PubChemID | 4364841 |
| InChIKey | YBEZORYMVISYOA-UHFFFAOYSA-N |
| Smiles | CCCC1=C(O)C(CC=O)=CC=C1OCCCOC1=CC=C(OCC(O)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.NaOH | 40.24 | 100 | |
| DMSO | 40.24 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight402.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.48mL | 12.42mL | 24.85mL |
| 5mM | 0.5mL | 2.48mL | 4.97mL |
| 10mM | 0.25mL | 1.24mL | 2.48mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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