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Description:Potent,selectiveNK1antagoNIST
ChemicalName:N-Acetyl-L-tryptophan3,5-bis(trifluoromethyl)benzylester
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentandhighlyselectivecompetitivetachykininNK1receptorantagonist(IC50=2.3nM).
LicensingInformation
SoldwiththepermissionofMerckSharpandDohmeLtd.
CompoundLibraries
L-732,138isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 472.39 |
| Formula | C22H18F6N2O3 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 148451-96-1 |
| PubChemID | 44396853 |
| InChIKey | BYYQYXVAWXAYQC-LJQANCHMSA-N |
| Smiles | O=C(N[C@@](CC2=CNC3=C2C=CC=C3)([H])C(OCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 47.24 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight472.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.12mL | 10.58mL | 21.17mL |
| 5mM | 0.42mL | 2.12mL | 4.23mL |
| 10mM | 0.21mL | 1.06mL | 2.12mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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