BiologicalActivity
PotentCB1receptorantagonist/inverseagonist(Ki=141nM)withgreaterthan70-foldselectivityoverCB2receptors(Ki>10μM).StructurallydissimilarfromSR141716AandAM251.Showsweakbindingtoboth5-HT2(Ki=6.4μM)andmuscarinicreceptors(Ki=2.1μM).
TechnicalData
| M.Wt | 383.4 |
| Formula | C24H17NO4 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 176977-56-3 |
| PubChemID | 5311257 |
| InChIKey | RYNSGDFWBJWWSZ-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C=C1)C1=C(C(=O)C2=CC=C(C=C2)C#N)C2=CC=C(OC)C=C2O1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.5 | 30 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight383.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.61mL | 13.04mL | 26.08mL |
| 5mM | 0.52mL | 2.61mL | 5.22mL |
| 10mM | 0.26mL | 1.3mL | 2.61mL |
| 50mM | 0.05mL | 0.26mL | 0.52mL |
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