BiologicalActivity
Potent,selective5-HT1Freceptoragonist(EC50=3nM).Displays>80-foldselectivityoverother5-HTreceptors(Kivaluesare0.006,0.53,0.55,0.56,1.42,1.70,3.50,3.94and4.85μMfor5-HT1F,5-HT1A,5-HT1B,5-HT1D,5-HT1E,5-HT2B,5-HT2C,5-HT2Aand5-HT7receptorsrespectively).Inhibitsneurogenicduralinflammationinvivofollowingi.v.andoraladministration.
LicensingInformation
SoldunderlicensefromEliLillyandCompany
CompoundLibraries
LY344864hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 387.88 |
| Formula | C21H22N3OF.HCl |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1217756-94-9 |
| PubChemID | 56972176 |
| InChIKey | OKUHLSYESBLBCP-PKLMIRHRSA-N |
| Smiles | Cl[H].CN(C)[C@@H]1CCC2=C(C1)C1=CC(NC(=O)C3=CC=C(F)C=C3)=CC=C1N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.79 | 100 | |
| ethanol | 1.93 | 5 | |
| water | 19.39 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight387.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.58mL | 12.89mL | 25.78mL |
| 5mM | 0.52mL | 2.58mL | 5.16mL |
| 10mM | 0.26mL | 1.29mL | 2.58mL |
| 50mM | 0.05mL | 0.26mL | 0.52mL |
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