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Description:InhibitsLyn-dependentactivitiesofIL-5receptor;cell-permeable
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Cell-permeableinhibitorofLyn-dependenteffectsoftheIL-5receptor.BlocksbindingofLyntyrosinekinasetoβcsubunitofIL-3/GM-CSF/IL-5receptors,blockingLynactivation.InhibitsIL-5receptor-mediatedeosinophildifferentiationandsurvivalinvitro.Inhibitsairwayeosinophilicinflammationinmousemodelofasthma.
TechnicalData
M.Wt | 2370.91 |
Formula | C115H184N30O24 |
Sequence | YGYRLRRKWEEKIPNP (Modifications:Tyr-1=Octadecanoyl-Tyr,Pro-16=C-terminalamide) |
Storage | Desiccateat-20°C |
CASNumber | 222018-18-0 |
PubChemID | 90001265 |
InChIKey | MITSVNFZLBORMW-QMGLJYLZSA-N |
Smiles | CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solubility | Solubleto10mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight2370.91.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.42mL | 2.11mL | 4.22mL |
5mM | 0.08mL | 0.42mL | 0.84mL |
10mM | 0.04mL | 0.21mL | 0.42mL |
50mM | 0.01mL | 0.04mL | 0.08mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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