BiologicalActivity
Potentandselectivegalaninreceptor2(GAL2)agonist(EC50=38nM,Kivaluesare6.55,497and587nMatGAL2,GAL3andGAL1respectively).Hasanadditiveeffectonthesignaltransductionofgalanin.
TechnicalData
| M.Wt | 2774.26 |
| Formula | C128H205N37O32 |
| Sequence | RGRGNWTLNSAGYLLGPVLPPPALALA (Modifications:Ala-27=C-terminalamide) |
| Storage | Desiccateat-20°C |
| CASNumber | 1172089-00-7 |
| PubChemID | 71744999 |
| InChIKey | XIHYPTIVAPJZFP-HEPWHOECSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto5mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight2774.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.36mL | 1.8mL | 3.6mL |
| 5mM | 0.07mL | 0.36mL | 0.72mL |
| 10mM | 0.04mL | 0.18mL | 0.36mL |
| 50mM | 0.01mL | 0.04mL | 0.07mL |
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