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Description:PotentSmoothened(Smo)receptorantagoNIST
ChemicalName:N-[[1-(2-Methoxyphenyl)-1H-indazol-5-yl]methyl]-2-propylpentanamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentSmoothened(Smo)receptorantagonist(IC50=5nM).InhibitstheHedgehogsignalingpathway.InhibitsShhinducedGliluciferasereporteractivityinShh-light2cells(IC50=5nM).AntagonizesGSA-10andSAG-mediateddifferentiationoftheC3H10T1/2cellline(IC50valuesare69and115nM,respectively).
CompoundLibraries
M25isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 379.5 |
Formula | C23H29N3O2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
PubChemID | 44250034 |
InChIKey | WATNXVHKRRTUFK-UHFFFAOYSA-N |
Smiles | O=C(C(CCC)CCC)NCC1=CC=C(N(C3=CC=CC=C3OC)N=C2)C2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 37.95 | 100 | |
ethanol | 37.95 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight379.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.64mL | 13.18mL | 26.35mL |
5mM | 0.53mL | 2.64mL | 5.27mL |
10mM | 0.26mL | 1.32mL | 2.64mL |
50mM | 0.05mL | 0.26mL | 0.53mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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