BiologicalActivity
PotentSmoothened(Smo)receptorantagonist(IC50=5nM).InhibitstheHedgehogsignalingpathway.InhibitsShhinducedGliluciferasereporteractivityinShh-light2cells(IC50=5nM).AntagonizesGSA-10andSAG-mediateddifferentiationoftheC3H10T1/2cellline(IC50valuesare69and115nM,respectively).
CompoundLibraries
M25isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 379.5 |
| Formula | C23H29N3O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 44250034 |
| InChIKey | WATNXVHKRRTUFK-UHFFFAOYSA-N |
| Smiles | O=C(C(CCC)CCC)NCC1=CC=C(N(C3=CC=CC=C3OC)N=C2)C2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.95 | 100 | |
| ethanol | 37.95 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight379.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.64mL | 13.18mL | 26.35mL |
| 5mM | 0.53mL | 2.64mL | 5.27mL |
| 10mM | 0.26mL | 1.32mL | 2.64mL |
| 50mM | 0.05mL | 0.26mL | 0.53mL |
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