Tocris型号参数规格 Tocris GPCR ligands,Tocris/MK 1903/4622/10/10 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/MK 1903/4622/10/10 mg

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Tocris

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4622/10

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Description:PotentandselectiveGPR109A(HCA₂)agoNIST

ChemicalName:(4aR,5aR)-4,4a,5,5a-Tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2]pyrazole-3-carboxylicacid

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectivehydroxycarboxylicacidreceptor2(HCA₂,GPR109A)fullagonist;exhibitsgreaterpotencythanniacininawholecellHTRF-cAMPassay(EC₅₀valuesare12.9and51nMrespectively).ExhibitsnobindingattheGRP109Breceptor.

TechnicalData

M.Wt	164.16
Formula	C₈H₈N₂O₂
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1268882-43-4
PubChemID	49763030
InChIKey	CUTZNERBKDMLAP-QWWZWVQMSA-N
Smiles	[H][C@@]12CC3=C(NN=C3C(O)=O)[C@@]([H])1C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	16.42	100
	ethanol	8.21	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight164.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	6.09mL	30.46mL	60.92mL
5mM	1.22mL	6.09mL	12.18mL
10mM	0.61mL	3.05mL	6.09mL
50mM	0.12mL	0.61mL	1.22mL

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