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Description:Potentandselective5-HT4partialagoNIST
ChemicalName:4-Amino-5-chloro-2-methoxybenzoicacid2-(1-piperidinyl)ethylesterhydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Potent5-HT4partialagonist(EC50=4nM)thatdisplays>680-foldselectivityover5-HT3receptors(Kivaluesare1.07and730nMrespectively).IncreasessAPPαlevelsinthecortexinananimalmodelofAlzheimer'sdiseaseandexhibitsprogastrokineticeffectsinvivo.
CompoundLibraries
ML10302hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 349.25 |
Formula | C15H21ClN2O3.HCl |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 186826-17-5 |
PubChemID | 56972230 |
InChIKey | HBLRTSYSGOFQCK-UHFFFAOYSA-N |
Smiles | ClC1=CC(C(OCCN2CCCCC2)=O)=C(OC)C=C1N.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 17.46 | 50 | |
ethanol | 6.99 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight349.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.86mL | 14.32mL | 28.63mL |
5mM | 0.57mL | 2.86mL | 5.73mL |
10mM | 0.29mL | 1.43mL | 2.86mL |
50mM | 0.06mL | 0.29mL | 0.57mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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