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Tocris/ML 10302 hydrochloride/3499/50/50 mg
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Tocris/ML 10302 hydrochloride/3499/50/50 mg
品牌 / 
Tocris
货号 / 
3499/50
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4000-520-616
Description:Potentandselective5-HT4partialagoNIST
ChemicalName:4-Amino-5-chloro-2-methoxybenzoicacid2-(1-piperidinyl)ethylesterhydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent5-HT4partialagonist(EC50=4nM)thatdisplays>680-foldselectivityover5-HT3receptors(Kivaluesare1.07and730nMrespectively).IncreasessAPPαlevelsinthecortexinananimalmodelofAlzheimer'sdiseaseandexhibitsprogastrokineticeffectsinvivo.

CompoundLibraries

ML10302hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt349.25
FormulaC15H21ClN2O3.HCl
StorageDesiccateatRT
Purity≥99%(HPLC)
CASNumber186826-17-5
PubChemID56972230
InChIKeyHBLRTSYSGOFQCK-UHFFFAOYSA-N
SmilesClC1=CC(C(OCCN2CCCCC2)=O)=C(OC)C=C1N.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO17.4650
ethanol6.9920

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight349.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.86mL14.32mL28.63mL
5mM0.57mL2.86mL5.73mL
10mM0.29mL1.43mL2.86mL
50mM0.06mL0.29mL0.57mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet