BiologicalActivity
Selective,highaffinitycompetitiveantagonistoftheP2Y1receptor(Ki=2.5nM;IC50=51.6nM).FailstoblocknucleotidesignalingatmostotherP2Yreceptors(P2Y2,P2Y4,P2Y6,P2Y11andP2Y12)andpotentlyinhibitsADP-inducedaggregationofhumanbloodplateletsinvitro(pKB=8.05).
LicensingInformation
SoldunderlicensefromtheNIH,USPatent10/169975
TechnicalData
| M.Wt | 503.78 |
| Formula | C13H18ClN5O8P2.2NH3 |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 367909-40-8 |
| PubChemID | 90488744 |
| InChIKey | MLPKPDFUVMQAOX-KOVKCLEESA-N |
| Smiles | ClC4=NC1=C(C(NC)=N4)N=CN1[C@H]2C[C@H](OP(O)(O)=O)[C@@]3(COP(O)(O)=O)[C@@H]2C3.N.N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 50.38 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight503.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.98mL | 9.92mL | 19.85mL |
| 5mM | 0.4mL | 1.98mL | 3.97mL |
| 10mM | 0.2mL | 0.99mL | 1.98mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |
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