进口试剂Tocris直采 Tocris神经传递素,Tocris/MRT 10/4585/50/50 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/MRT 10/4585/50/50 mg

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Tocris

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4585/50

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4000-520-616

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Description:Smoothened(Smo)antagoNIST

ChemicalName:N-[[[3-Benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-trimethoxybenzamide

Purity:≥98%

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Smoothened(Smo)receptorantagonist(IC₅₀=0.5μMinHEK293cellstransientlyexpressingmouseSmo).InhibitsShhN-inducedGliluciferasereporteractivityinShh-light2cells(IC₅₀=2.5μM);actsasaninverseagonistduringnontranscriptionalHedgehogpathwayactivation(IC₅₀=2.5μMinHEK293cells).

TechnicalData

M.Wt	465.52
Formula	C₂₄H₂₃N₃O₅S
Storage	Storeat+4°C
Purity	≥98%
CASNumber	330829-30-6
PubChemID	1139102
InChIKey	KVQVEZQDNHMQJV-UHFFFAOYSA-N
Smiles	O=C(NC(NC2=CC(NC(C3=CC=CC=C3)=O)=CC=C2)=S)C1=CC(OC)=C(OC)C(OC)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	46.55	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight465.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.15mL	10.74mL	21.48mL
5mM	0.43mL	2.15mL	4.3mL
10mM	0.21mL	1.07mL	2.15mL
50mM	0.04mL	0.21mL	0.43mL

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