![Tocris/[Nle<sup>4</sup>,D-Phe<sup>7</sup>]-<em class='symbol'>α</em>-MSH/3013/1/1 mg](images/201712/1512521756115821138.jpg)
BiologicalActivity
Syntheticanalogofα-MSHthatisanagonistatmelanocortinreceptors(Kivaluesare0.085,0.4,3.8and5.1nMforMC1,MC3,MC4andMC5receptorsrespectively).
TechnicalData
| M.Wt | 1646.86 |
| Formula | C78H111N21O19 |
| Sequence | SYSXEHFRWGKPV (Modifications:Ser-1=N-terminalAc,X=Nle,Phe-7=D-Phe,Val-13=C-terminalamide) |
| Storage | Desiccateat-20°C |
| CASNumber | 75921-69-6 |
| PubChemID | 16132139 |
| InChIKey | UAHFGYDRQSXQEB-PWPYQVNISA-N |
| Smiles | CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto0.60mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1646.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.61mL | 3.04mL | 6.07mL |
| 5mM | 0.12mL | 0.61mL | 1.21mL |
| 10mM | 0.06mL | 0.3mL | 0.61mL |
| 50mM | 0.01mL | 0.06mL | 0.12mL |
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