BiologicalActivity
Endogenousmelanocortinreceptoragonist(Kivaluesare0.12,31,660and5700nMforMC1,MC3,MC4andMC5receptorsrespectively).Anti-inflammatorypeptide;antagonizesproinflammatorymediators,includingTNF-α,IL-6andNOandinducesanti-inflammatorycytokineIL-10.Inhibitsfoodintakeandinducespenileerectionsfollowingi.c.v.administration.
TechnicalData
| M.Wt | 1664.9 |
| Formula | C77H109N21O19S |
| Sequence | SYSMEHFRWGKPV (Modifications:Ser-1=N-terminalAc,Val-13=C-terminalamide) |
| Storage | Desiccateat-20°C |
| CASNumber | 581-05-5 |
| PubChemID | 16132144 |
| InChIKey | WHNFPRLDDSXQCL-UAZQEYIDSA-N |
| Smiles | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto0.60mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1664.9.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.6mL | 3mL | 6.01mL |
| 5mM | 0.12mL | 0.6mL | 1.2mL |
| 10mM | 0.06mL | 0.3mL | 0.6mL |
| 50mM | 0.01mL | 0.06mL | 0.12mL |
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