Tocris信号通路抑制剂 Tocris化合物筛选文库,Tocris/Maraviroc/3756/50/50 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/Maraviroc/3756/50/50 mg

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Tocris

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3756/50

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4000-520-616

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Description:SelectiveCCR5antagoNIST

AlternativeNames:UK-427857

ChemicalName:4,4-Difluoro-N-{(1S)-3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azABIcyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveCCR5antagonist;displayspotentanti-HIV-1activity.PreventstheinteractionofHIV-1gp120andCCR5(IC₅₀=6.4nM),inhibitingHIV-1entry.Exhibitsantinociceptiveeffectsinaratmodelofneuropathicpain.AlsoinhibitsCCL3(MIP-1α)bindingtoCCR5.Orallybioavailable.

LicensingInformation

SoldforresearchpurposesunderagreementfromViiv.

CompoundLibraries

MaravirocisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	513.67
Formula	C₂₉H₄₁F₂N₅O
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	376348-65-1
PubChemID	483407
InChIKey	GSNHKUDZZFZSJB-ILVMPNSOSA-N
Smiles	O=C(C4CCC(F)(F)CC4)N[C@@H](CCN2C3CCC2CC(N5C(C)=NN=C5C(C)C)C3)C1=CC=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	38.53	75
	ethanol	51.37	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight513.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.95mL	9.73mL	19.47mL
5mM	0.39mL	1.95mL	3.89mL
10mM	0.19mL	0.97mL	1.95mL
50mM	0.04mL	0.19mL	0.39mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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