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Description:HumanpregnaneXreceptoragoNIST;H1antagonist
AlternativeNames:Meclozine
ChemicalName:1-[(4-Chlorophenyl)phenylmethyl]4-[(3-methylphenyl)methyl]piperazinedihydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
HumanpregnaneXreceptor(hPXR)agonist;strongeractivatorofhPXRthanratPXR.IncreaseshPXRtargetgeneexpressioninhumanhepatocyteprimarycultures.AlsoactsasahistamineH1receptorantagonist.ConfersneuroprotectioninmodelsofpolyQtoxicity.
CompoundLibraries
MeclizinedihydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 463.87 |
Formula | C25H27ClN2.2HCl |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 1104-22-9 |
PubChemID | 64713 |
InChIKey | VCTHNOIYJIXQLV-UHFFFAOYSA-N |
Smiles | CC1=CC(CN(CC4)CCN4C(C3=CC=C(Cl)C=C3)C2=CC=CC=C2)=CC=C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 23.19 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight463.87.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.16mL | 10.78mL | 21.56mL |
5mM | 0.43mL | 2.16mL | 4.31mL |
10mM | 0.22mL | 1.08mL | 2.16mL |
50mM | 0.04mL | 0.22mL | 0.43mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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