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Description:Selectivenon-peptideCRF1antagoNIST
ChemicalName:5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediaminehydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Selective,non-peptidecorticotropin-releasingfactor1(CRF1)receptorantagonist(Ki=1.7nM);hasnoactivityatCRF2receptors.Blocksbehavioralseizuresinvivo.
CompoundLibraries
NBI27914hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 470.66 |
| Formula | C18H20Cl4N4.HCl |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 1215766-76-9 |
| PubChemID | 45073446 |
| InChIKey | CPMGENCTAWBLNW-UHFFFAOYSA-N |
| Smiles | Cl.CCCN(CC1CC1)C1=C(Cl)C(NC2=C(Cl)C=C(Cl)C=C2Cl)=NC(C)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.42 | 100 | |
| ethanol | 43.42 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight470.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.12mL | 10.62mL | 21.25mL |
| 5mM | 0.42mL | 2.12mL | 4.25mL |
| 10mM | 0.21mL | 1.06mL | 2.12mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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