BiologicalActivity
Potentandselectiveσ1receptorantagonist(Ki=0.86nM)thatdisplays>55-foldselectivityoverσ2receptorsand>6000-foldselectivityoverD1,D2,5-HT1A,5-HT2andPCPreceptors.ExhibitsreversIBLebinding(Kd=1.2nM)anddisplaysantipsychoticactivityinvivo.Orallyactive.
CompoundLibraries
NE100hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 391.97 |
| Formula | C23H33NO2.HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 149409-57-4 |
| PubChemID | 9952420 |
| InChIKey | ZHGMDXSHODHWHV-UHFFFAOYSA-N |
| Smiles | CCCN(CCC)CCC1=CC=C(OC)C(OCCC2=CC=CC=C2)=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.2 | 100 | |
| water | 9.8 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight391.97.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.55mL | 12.76mL | 25.51mL |
| 5mM | 0.51mL | 2.55mL | 5.1mL |
| 10mM | 0.26mL | 1.28mL | 2.55mL |
| 50mM | 0.05mL | 0.26mL | 0.51mL |
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