BiologicalActivity
PotentandselectivedopamineD3receptorantagonist(Kivaluesare1.4,217,223,642,>5000,>10000and>10000nMforD3,D2,5-HT2,α1,D4,D1andD5receptorsrespectively).Potentlyantagonizesquinpirole-stimulatedmitogenesis(IC50=6.8nM).Attenuatescocaine'srewardingeffectsandinhibitsrelapsetodrug-seekingbehavior.
CompoundLibraries
NGB2904isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 530.92 |
| Formula | C28H29Cl2N3O.HCl |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 189061-11-8 |
| PubChemID | 19366304 |
| InChIKey | PFIWYJNBKGCVFM-UHFFFAOYSA-N |
| Smiles | Cl.ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNC(=O)C2=CC=C3C(CC4=CC=CC=C34)=C2)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.27 | 25 | |
| ethanol | 2.65 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight530.92.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.88mL | 9.42mL | 18.84mL |
| 5mM | 0.38mL | 1.88mL | 3.77mL |
| 10mM | 0.19mL | 0.94mL | 1.88mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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