BiologicalActivity
SelectiveCa2+-sensingreceptorantagonist.BlocksincreasesincytoplasmicCa2+concentrationselicitedbyhumanCa2+receptorsexpressedinHEK293cells(IC50=43nM).Alsostimulatesparathyroidhormonesecretionfrombovineparathyroidcells(EC50=41nM).Orallyactivecalcilyticcompound.
CompoundLibraries
NPS2143hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 445.38 |
| Formula | C24H25ClNO2.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 324523-20-8 |
| PubChemID | 9868131 |
| InChIKey | ZEBNDUQLNGYBNL-VEIFNGETSA-N |
| Smiles | CC(NC[C@@H](O)COC3=C(C#N)C(Cl)=CC=C3)(C)CC2=CC1=CC=CC=C1C=C2.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.54 | 100 | |
| ethanol | 4.45 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight445.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.25mL | 11.23mL | 22.45mL |
| 5mM | 0.45mL | 2.25mL | 4.49mL |
| 10mM | 0.22mL | 1.12mL | 2.25mL |
| 50mM | 0.04mL | 0.22mL | 0.45mL |
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