BiologicalActivity
Non-steroidalandsilentantiandrogen.Bindstoandrogenreceptorsandalsoinhibitsandrogenbiosynthesisinvitro.Inratsinvivoitinhibitsandrogen-inducedprostateweightincreaseandinhibitsnegativeandrogen-dependentgonadotropinfeedbackleADIngtoanincreaseinluteinisinghormoneandtestosterone.Orallyactive.
TechnicalData
| M.Wt | 317.22 |
| Formula | C12H10F3N3O4 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 63612-50-0 |
| PubChemID | 4493 |
| InChIKey | XWXYUMMDTVBTOU-UHFFFAOYSA-N |
| Smiles | CC1(C)NC(=O)N(C1=O)C1=CC=C(C(=C1)C(F)(F)F)N(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.93 | 25 | |
| ethanol | 7.93 | 25mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight317.22.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.15mL | 15.76mL | 31.52mL |
| 5mM | 0.63mL | 3.15mL | 6.3mL |
| 10mM | 0.32mL | 1.58mL | 3.15mL |
| 50mM | 0.06mL | 0.32mL | 0.63mL |
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