![Tocris/[Nphe<sup>1</sup>]Nociceptin(1-13)NH<sub>2</sub>/1308/1/1 mg](images/201712/1512585220180220556.jpg)
BiologicalActivity
Selectiveandcompetitivenociceptinreceptorantagonist,devoidofanyagonistactivity.Bindsselectivelytorecombinantnociceptinreceptors(pKi=8.4),andcompetitivelyantagonizestheactionsofnociceptininvitroandinvivo.
TechnicalData
| M.Wt | 1381.6 |
| Formula | C61H100N22O15 |
| Sequence | GGGFTGARKSARK (Modifications:Gly-1=N-Bn-Gly,Lys-13=C-terminalamide) |
| Storage | Desiccateat-20°C |
| CASNumber | 267234-08-2 |
| PubChemID | 10654047 |
| InChIKey | NMBZIPCESQREMT-UVDGFCMYSA-N |
| Smiles | [H]N(CC(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O)CC1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlin10%acetonitrile |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1381.6.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.72mL | 3.62mL | 7.24mL |
| 5mM | 0.14mL | 0.72mL | 1.45mL |
| 10mM | 0.07mL | 0.36mL | 0.72mL |
| 50mM | 0.01mL | 0.07mL | 0.14mL |
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