BiologicalActivity
5-HT1Bselectiveagonist,severaltimesmorepotentthansumatriptanandinactiveasa5-HT1Aagonist(Kiat5-HT1B=1nM,selectivityover5-HT1A>300-fold).Mimicspolysialicacidactivity,stimulatesneuritogenesis,myelinationandSchwanncellmigrationinvitro.
TechnicalData
| M.Wt | 392.49 |
| Formula | C19H30N2O.C2H2O4 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 157798-13-5 |
| PubChemID | 10126593 |
| InChIKey | JORSCLBFSAAOFR-UHFFFAOYSA-N |
| Smiles | OC(=O)C(O)=O.CCCCCCCCCOC1=CC=C2NC=C(CCN)C2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.25 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight392.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.55mL | 12.74mL | 25.48mL |
| 5mM | 0.51mL | 2.55mL | 5.1mL |
| 10mM | 0.25mL | 1.27mL | 2.55mL |
| 50mM | 0.05mL | 0.25mL | 0.51mL |
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