BiologicalActivity
Highaffinityσ2receptoragonist(Kivaluesare0.8and15.2nMforσ2andσ1receptorsrespectively)thatdisplaysminimalaffinityatotherreceptors.Inhibitselectricallyevokedtwitchinguineapigbladderandileum(EC50valuesare2.62and3.96μMrespectively).DisplaysantiproliferativeandcytotoxiceffectsinSK-N-SHneuroblastomaandC6gliomacells.
TechnicalData
| M.Wt | 443.5 |
| Formula | C24H38N2O.2HCl |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 172907-03-8 |
| PubChemID | 46861545 |
| InChIKey | DSRBJOQIBXACIV-UHFFFAOYSA-N |
| Smiles | O=C1C=C(C)C(/C(C)=N/C2=C(N)C=CC=C2)=C(O)N1O.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.87 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight443.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.25mL | 11.27mL | 22.55mL |
| 5mM | 0.45mL | 2.25mL | 4.51mL |
| 10mM | 0.23mL | 1.13mL | 2.25mL |
| 50mM | 0.05mL | 0.23mL | 0.45mL |
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