BiologicalActivity
AspecificPAFantagonist,morepotentthantheginkolideBN-52021.InhibitsrabbitplateletaggregationwithanIC50valueof1.05μMandhasnosignificantactivityonCa2+channels.Activeinvivo,antagonizingPAF-inducedsystemichypotensionandprotein-plasmaextravasationinrats.
CompoundLibraries
PCA4248isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 361.46 |
| Formula | C19H23NO4S |
| Storage | Desiccateat-20°C |
| Purity | ≥95% |
| CASNumber | 123875-01-4 |
| PubChemID | 4698 |
| InChIKey | DHCNAWNKZMNTIS-UHFFFAOYSA-N |
| Smiles | COC(=O)C1=C(C)NC(C)=C(C1C)C(=O)OCCSC1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.14 | 100 | |
| ethanol | 36.14 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight361.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.77mL | 13.83mL | 27.67mL |
| 5mM | 0.55mL | 2.77mL | 5.53mL |
| 10mM | 0.28mL | 1.38mL | 2.77mL |
| 50mM | 0.06mL | 0.28mL | 0.55mL |
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