BiologicalActivity
Highaffinity,selectiveσ1ligand(Kivaluesare0.08and1377nMforσ1andσ2respectively).Displaysnosignificantactivityatawiderangeofotherreceptors,ionchannelsandenzymes.Antagonizesmescaline-inducedscratchinginmicefollowingi.p.admiNISTration.Alsoattenuatescocaine-inducedhyperactivityinmice.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
TechnicalData
| M.Wt | 372.42 |
| Formula | C18H22N2O.C2H2O4 |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 154130-99-1 |
| PubChemID | 9817231 |
| InChIKey | FOQRKFCLRMMKAT-UHFFFAOYSA-N |
| Smiles | O=C(O)C(O)=O.CCCN1CC(C2=CC(C3=CC=C(C)C=C3)=NO2)=CCC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.62 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight372.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.69mL | 13.43mL | 26.85mL |
| 5mM | 0.54mL | 2.69mL | 5.37mL |
| 10mM | 0.27mL | 1.34mL | 2.69mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
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