BiologicalActivity
Selectivenon-steroidalandrogenreceptor(AR)antagonist(IC50valuesare26nMand90nMinARbindingassaysandcellularassaysrespectively).Displayslowaffinityforprogesteronereceptor(IC50>10μM).Activeinvivo.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
TechnicalData
| M.Wt | 269.26 |
| Formula | C14H14F3NO |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1076225-27-8 |
| PubChemID | 25093231 |
| InChIKey | MENRRRXHFQYXDW-DGCLKSJQSA-N |
| Smiles | O[C@H](CCCC2)[C@H]2[C@]1=CC(C(F)(F)F)=C(C#N)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.93 | 100 | |
| ethanol | 26.93 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight269.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.71mL | 18.57mL | 37.14mL |
| 5mM | 0.74mL | 3.71mL | 7.43mL |
| 10mM | 0.37mL | 1.86mL | 3.71mL |
| 50mM | 0.07mL | 0.37mL | 0.74mL |
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