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Description:SmoreceptoragoNIST
ChemicalName:9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Smoothened(Smo)receptoragonist(EC50~1μM).InducesosteogenesisinmousemesenchymalProgenitorcells(C3H10T1/2).WhencombinedwithBMP-4,cantransdifferentiatepre-ADIpocytes(3T3-L1)andmyoblasts(C2C12)intoosteoblasts.Inducesdifferentiationofmultipotentmesenchymalprogenitorcellsintoosteoblasts.
CompoundLibraries
PurmorphamineisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 520.62 |
Formula | C31H32N6O2 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 483367-10-8 |
PubChemID | 5284329 |
InChIKey | FYBHCRQFSFYWPY-UHFFFAOYSA-N |
Smiles | C1(OC4=CC=CC5=C4C=CC=C5)=NC(NC3=CC=C(N6CCOCC6)C=C3)=C2C(N(C7CCCCC7)C=N2)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 52.06 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight520.62.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.92mL | 9.6mL | 19.21mL |
5mM | 0.38mL | 1.92mL | 3.84mL |
10mM | 0.19mL | 0.96mL | 1.92mL |
50mM | 0.04mL | 0.19mL | 0.38mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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