BiologicalActivity
Smoothened(Smo)receptoragonist(EC50~1μM).InducesosteogenesisinmousemesenchymalProgenitorcells(C3H10T1/2).WhencombinedwithBMP-4,cantransdifferentiatepre-ADIpocytes(3T3-L1)andmyoblasts(C2C12)intoosteoblasts.Inducesdifferentiationofmultipotentmesenchymalprogenitorcellsintoosteoblasts.
CompoundLibraries
PurmorphamineisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 520.62 |
| Formula | C31H32N6O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 483367-10-8 |
| PubChemID | 5284329 |
| InChIKey | FYBHCRQFSFYWPY-UHFFFAOYSA-N |
| Smiles | C1(OC4=CC=CC5=C4C=CC=C5)=NC(NC3=CC=C(N6CCOCC6)C=C3)=C2C(N(C7CCCCC7)C=N2)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.06 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight520.62.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.92mL | 9.6mL | 19.21mL |
| 5mM | 0.38mL | 1.92mL | 3.84mL |
| 10mM | 0.19mL | 0.96mL | 1.92mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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