BiologicalActivity
Selectiveandhighaffinity5-HT6antagonist(pKi=8.9);displayslowhERGinhibition.Exhibits>100foldselectivityagainstapanelof50targetsincludingother5-HTreceptorsubtypes.Brainpenetrant.
CompoundLibraries
R1485dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 450.35 |
| Formula | C18H20FN3O3S.2HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 90488993 |
| InChIKey | SNXURKRGPYXWRN-UHFFFAOYSA-N |
| Smiles | FC(C=CC=C4)=C4S(N2CCOC1=C(N3CCNCC3)C=CC=C12)(=O)=O.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.03 | 100 | |
| water | 45.03 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight450.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.22mL | 11.1mL | 22.2mL |
| 5mM | 0.44mL | 2.22mL | 4.44mL |
| 10mM | 0.22mL | 1.11mL | 2.22mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
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ProductDatasheets
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