BiologicalActivity
InhibitorofTNF-αreceptor1(TNFR1)signaling;blocksTNFR1associationwithTRADDandRIP1.InhibitsTNF-α-inducedNF-κBandMAPKsignalingpathwayactivation.Attenuatesintracerebralhemorrhage-inducedneurovascularinjuryinmice.
TechnicalData
| M.Wt | 380.77 |
| Formula | C16H8ClF3N4S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 303997-35-5 |
| PubChemID | 1486608 |
| InChIKey | SUUMKHOVGVYGOP-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(N=C(SC4=CC=CC=C4)C2=NN=C(C(F)(F)F)N23)C3=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.62 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight380.77.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.63mL | 13.13mL | 26.26mL |
| 5mM | 0.53mL | 2.63mL | 5.25mL |
| 10mM | 0.26mL | 1.31mL | 2.63mL |
| 50mM | 0.05mL | 0.26mL | 0.53mL |
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