BiologicalActivity
Apotentandselective5-HT4antagonist,withapKiof9.1at5-HT4receptorsinguineapigstriatalmembranesandgreaterthan1000-foldselectivityover5-HT1A,2C,3andD1,D2,M1,M2,AT1,B1andα1Creceptors.TheketonegroupgivesRS39604arelativelylonghalflife;itisalsoorallyactiveandsosuitableforinvivostudies.
LicensingInformation
SoldwiththepermissionofRocheBioscience
TechnicalData
| M.Wt | 590.56 |
| Formula | C26H36ClN3O6S.HCl |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 167710-87-4 |
| PubChemID | 19081934 |
| InChIKey | QSMYZGMJSGUWPM-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC(OC)=CC(COC2=CC(N)=C(Cl)C=C2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 59.06 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight590.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.69mL | 8.47mL | 16.93mL |
| 5mM | 0.34mL | 1.69mL | 3.39mL |
| 10mM | 0.17mL | 0.85mL | 1.69mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
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