BiologicalActivity
Apotentandhighlyselective5-HT4partialagonist,withpKivaluesof8.7at5-HT4sitesinguineapigstriatumand>6atvariousotherreceptors,including5-HT1A,1D,2A,2C,D1,D2andM1-3.Activeinvivo,withanintrinsicactivityrelativeto5-HTof0.5.
LicensingInformation
SoldwiththepermissionofRocheBioscience
TechnicalData
| M.Wt | 389.36 |
| Formula | C19H29ClN2O2.HCl |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 168986-60-5 |
| PubChemID | 9800491 |
| InChIKey | XVBGLZNYWUUAFF-UHFFFAOYSA-N |
| Smiles | Cl.CCCCN1CCC(CCC(=O)C2=CC(Cl)=C(N)C=C2OC)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.73 | 25mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight389.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.57mL | 12.84mL | 25.68mL |
| 5mM | 0.51mL | 2.57mL | 5.14mL |
| 10mM | 0.26mL | 1.28mL | 2.57mL |
| 50mM | 0.05mL | 0.26mL | 0.51mL |
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