BiologicalActivity
PositiveallostericmodulatorofmGlu1receptors.Potentiatesglutamate-inducedcalciumrelease(EC50=60.1nMatratmGluR1a).DisplaysnoactivityathumanmGlu1receptors.
CompoundLibraries
Ro67-7476isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 319.39 |
| Formula | C17H18FNO2S |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 298690-60-5 |
| PubChemID | 32681978 |
| InChIKey | DAEHFYNGSSBGSS-KRWDZBQOSA-N |
| Smiles | FC(C=C2)=CC=[C@@]2[C@@H]1CCCN1S(C3=CC=C(C)C=C3)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.94 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight319.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.13mL | 15.65mL | 31.31mL |
| 5mM | 0.63mL | 3.13mL | 6.26mL |
| 10mM | 0.31mL | 1.57mL | 3.13mL |
| 50mM | 0.06mL | 0.31mL | 0.63mL |
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