BiologicalActivity
PotentandselectivePPARγagonist(EC50=60nM);exhibitsnoactivityatPPARαandPPARβ.PromotesdifferentiationofpluripotentC3H10T1/2stemcellsintoADIpocytes.Exhibitsantihyperglycemicactivityindiabeticob/obmousemodel.Antidiabeticagent.
CompoundLibraries
RosiglitazoneisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 357.43 |
| Formula | C18H19N3O3S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 122320-73-4 |
| PubChemID | 77999 |
| InChIKey | YASAKCUCGLMORW-UHFFFAOYSA-N |
| Smiles | CN(CCOC1=CC=C(CC2SC(NC2=O)=O)C=C1)C3=CC=CC=N3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 35.74 | 100 | |
| DMSO | 35.74 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight357.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.8mL | 13.99mL | 27.98mL |
| 5mM | 0.56mL | 2.8mL | 5.6mL |
| 10mM | 0.28mL | 1.4mL | 2.8mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |
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