Tocris试剂采购 Tocris Bioscience产品目录价格,Tocris/SB 224289 hydrochloride/1221/50/50 mg,受体,Tocris,Bio-Techne,,50 mg蚂蚁淘商城

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Tocris/SB 224289 hydrochloride/1221/50/50 mg

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Tocris/SB 224289 hydrochloride/1221/50/50 mg

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Tocris

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1221/50

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4000-520-616

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Description:Selective5-HT_1BantagoNIST

ChemicalName:1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxADIazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidinehydrochloride

Purity:≥95%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selective5-HT_1Breceptorantagonist(pK_i=8.2).Displays>60-foldselectivityover5-HT_1D,5-HT_1A,5-HT_1E,5-HT_1F,5-HT_2Aand5-HT_2Creceptorsinradioligandbindingandfunctionalassays.Centrallyactivefollowingoraladministrationinvivo.

LicensingInformation

SoldwiththepermissionofGlaxoSmithKline

TechnicalData

M.Wt	557.09
Formula	C₃₂H₃₂N₄O₃.HCl
Storage	Storeat-20°C
Purity	≥95%(HPLC)
CASNumber	180084-26-8
PubChemID	11226716
InChIKey	GKGKBZYMDILCOF-UHFFFAOYSA-N
Smiles	O=C(C5=CC=C(C6=CC=C(C7=NOC(C)=N7)C=C6C)C=C5)N2C1=CC3=C(OCC43CCN(CC4)C)C=C1CC2.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	5.57	10mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight557.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.8mL	8.98mL	17.95mL
5mM	0.36mL	1.8mL	3.59mL
10mM	0.18mL	0.9mL	1.8mL
50mM	0.04mL	0.18mL	0.36mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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PreparingStockSolutions

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