进口试剂Tocris直采 Tocris Bioscience试剂产品信息,Tocris/SB 228357/1375/50/50 mg,受体,Tocris,Bio-Techne,,50 mg蚂蚁淘商城

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Tocris/SB 228357/1375/50/50 mg

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Tocris

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1375/50

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4000-520-616

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Description:5-HT_2C/2BantagoNIST/inverseagonist

ChemicalName:N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

5-HT_2C/2Breceptorantagonist(pK_ivaluesare7.0,8.1and9.1at5-HT_2A,_2Band_2Creceptorsrespectively).Displaysinverseagonismina5-HT-stimulatedPIhydrolysismodelof5-HT_2Creceptorfunction.Orallyactiveinvivo.

LicensingInformation

Soldunderlicense

CompoundLibraries

SB228357isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	431.39
Formula	C₂₂H₁₇F₄N₃O₂
Storage	StoreatRT
Purity	≥99%(HPLC)
CASNumber	181629-93-6
PubChemID	443390
InChIKey	RRJLJKRFFRZRAF-UHFFFAOYSA-N
Smiles	COC1=C(C=C2N(CCC2=C1)C(=O)NC1=CC(F)=CC(=C1)C1=CC=CN=C1)C(F)(F)F

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	43.14	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight431.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.32mL	11.59mL	23.18mL
5mM	0.46mL	2.32mL	4.64mL
10mM	0.23mL	1.16mL	2.32mL
50mM	0.05mL	0.23mL	0.46mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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